| 单词 | myasthenia | ||||||
| 释义 | myastheniamy·as·the·ni·aM0506100 (mī′əs-thē′nē-ə)myasthenia(ˌmaɪəsˈθiːnɪə)my•as•the•ni•a(ˌmaɪ əsˈθi ni ə)n.
Myastheniamyasthenia[‚mī·əs·thēn·ē·ə]Myasthenia(asthenic bulbar paralysis, asthenic ophthalmoplegia, pseudobulbar paralysis, Erb-Goldflam disease), a neuromuscular disease characterized by the pathological, rapid fatigability of striated muscles. The onset of myasthenia usually occurs between the ages of 20 and 40 years; women are more frequently affected, Autoimmune processes play a part in the development of the disease; antibodies have been discovered in muscle tissue and in the thymus gland. The muscles of the eyelids are often affected and there is ptosis, which varies in degree during the day; the masticatory muscles are affected, swallowing is disrupted, and the gait changes. Treatment includes anticholinesterase preparations, vitamins (especially B-group), general restorative treatment, and sometimes the removal of the thymus gland. REFERENCESLobzin, V. S. Miasteniia. Leningrad, 1960.Shefer, D. G. Gipotalamicheskie (dientsefal’nye) sindromy, 2nd ed. Moscow, 1971. myastheniamyasthenia[mi″as-the´ne-ah]Symptoms of myasthenia gravis include ptosis, diplopia, and difficulty in chewing and swallowing. Weakness of the upper and lower limbs usually is first noted when the patient tries to walk upstairs, gets up from a sitting position, raises arms over the head, or lifts a heavy object. Ventilatory deficiency due to weakness of the respiratory muscles occurs in those with a severe form of the disease. About 20 per cent of all affected patients have only ocular myasthenia; the others have some form of generalized weakness. The presence of acetylcholine receptor antibodies is elevated in patients with myasthenia gravis. Diagnosis is established when there is a favorable response to cholinergic drugs, which are inhibitors of acetylcholinesterase (an enzyme that breaks down acetylcholine); their action permits acetylcholine levels to become high enough to stimulate the postsynaptic receptors. Children born of mothers with the disease exhibit a transient weakness that is evident at birth or may appear in the first day or so, with feeding difficulties manifested by poor sucking and swallowing abilities. They rarely have bulbar involvement, and usually recover in a week or so after birth. This condition is called neonatal myasthenia, and is related to circulating antibodies acquired from the mother while the fetus was in utero. Congenital myasthenia is also present at birth, but it may not be evident until after the first year of life. The child produces antibodies against acetylcholine receptor sites and experiences symptoms similar to those presented by myasthenia gravis patients of all ages. The patient is started on anticholinesterase drugs, such as neostigmine or pyridostigmine, as soon as the diagnosis is confirmed. The steroid prednisone and other immunosuppressive drugs provide some relief of symptoms and longer periods of remission. thymectomy is an alternative treatment for those patients whose weakness and debility do not respond adequately to cholinergic drug therapy. plasma exchange to remove the circulating autoantibodies provides some clinical improvement. High-dose intravenous globulin" >immune globulin may also be used to temporarily improve immune function. crisis" >Myasthenic crisis can develop suddenly after a systemic infection, surgery, or some other stressful event. The crisis usually is transient, but during the critical phase assisted ventilation and intensive care are needed to assure survival of the patient with respiratory failure.  my·as·the·ni·a(mī'as-thē'nē-ă),myasthenia(mī′əs-thē′nē-ə)my·as·the·ni·a(mī'as-thē'nē-ă)myastheniaMuscle weakness. Myasthenia is a feature of widespread cancer.my·as·the·ni·a(mī'as-thē'nē-ă)myasthenia
Synonyms for myasthenia
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