LMWH

Abbreviation for low molecular weight heparin.

heparin

(hep'a-rin) [ hepar + -in] A parenteral anticoagulant drug with a faster onset than warfarin or its derivatives. It is composed of polysaccharides that inhibit coagulation by forming an antithrombin that prevents conversion of prothrombin to thrombin and by preventing liberation of thromboplastin from platelets. Because heparin is poorly absorbed from the gastrointestinal tract, it is usually administered intravenously or subcutaneously as a sodium or calcium salt.

Uses

Heparin is used as an anticoagulant to prevent and treat thrombosis and embolism. It is an important agent in the management of acute coronary syndromes (e.g., unstable angina pectoris or acute myocardial infarction). Because heparin compounds are too large to cross the placental barrier, they are the preferred anticoagulants in pregnant women. The antagonist for an overdose is protamine sulfate. The most common side effect of heparin is abnormal bleeding.

heparin lock

A device attached to an intravenous catheter to prevent it from clotting. It is used for intermittent administration of fluids or medication. See: heparin lock flush solution; venous access device

low molecular weight heparin

Abbreviation: LMWH
The most bioavailable fraction of heparin. It has a more precise anticoagulant effect than unfractionated heparins and is used to prevent and treat deep venous thrombosis, pulmonary embolism, and acute coronary syndromes.

CAUTION!

It should be used selectively, if at all, in patients with reduced kidney function.

heparitin sulfate

A sulfurated mucopolysaccharide that accumulates in the connective tissue in abnormal amounts in some mucopolysaccharidoses. See: mucopolysaccharidosis

low molecular weight heparin

CAUTION!

It should be used selectively, if at all, in patients with reduced kidney function. See also: heparin