ABCC9

A gene on chromosome 12p12.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC9 appears to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle, and may have a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive K+ channels.
Molecular pathology
ABCC9 mutations are linked to dilated cardiomyopathy type 1O.

单词	abcc9
释义	ABCC9 ABCC9 A gene on chromosome 12p12.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC9 appears to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle, and may have a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive K+ channels. Molecular pathology ABCC9 mutations are linked to dilated cardiomyopathy type 1O.
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