maturity onset diabetes of the young type 2
maturity onset diabetes of the young type 2
An autosomal dominant endocrinopathy (OMIM:125851) of childhood to early adult onset, which is characterised by a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.Molecular pathology
Caused by defects in GCK on chromosome 7p15.3-p15.1, which encodes a glucokinase that phosphorylates glucose, the first usual step in glucose metabolism.