maturity onset diabetes of the young type 11

An autosomal dominant (OMIM:613375 )condition characterised by diabetes of childhood or early-adulthood onse (usually before 25 years of age), a primary defect in insulin secretion and insulin-independence at the beginning of the disease.
Molecular pathology
Caused by defects in BLK, which encodes a nonreceptor tyrosine-kinase that is involved in cell proliferation and differentiation, upregulates insulin synthesis and secretion in response to glucose, and enhances expression of pancreatic beta-cell transcription factors.

单词	maturity onset diabetes of the young type 11
释义	maturity onset diabetes of the young type 11 maturity onset diabetes of the young type 11 An autosomal dominant (OMIM:613375 )condition characterised by diabetes of childhood or early-adulthood onse (usually before 25 years of age), a primary defect in insulin secretion and insulin-independence at the beginning of the disease. Molecular pathology Caused by defects in BLK, which encodes a nonreceptor tyrosine-kinase that is involved in cell proliferation and differentiation, upregulates insulin synthesis and secretion in response to glucose, and enhances expression of pancreatic beta-cell transcription factors.
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