matrix metalloproteinase 8
matrix metalloproteinase 8
An enzyme encoded on chromosome 11q21-q22 which degrades collagens and other tissue substrates.Cytokine inducers
IL-1β, TNF-α.
Substrates
Collagens I, II, III, V, VII, VIII and X; gelatin; aggrecan; α1-AT; α1-ACHYM; α2-antiplasmin; fibronectin.