释义 |
methylmalonic acid
methylmalonic acid [meth″il-mah-lon´ik] a carboxylic acid that is a structural isomer of succinic acid; occurring in excess in the blood and other body fluids in methylmalonicacidemia.meth·yl·ma·lon·ic ac·id (meth'il-mă-lon'ik as'id), 2-Methylpropanedioic acid, an important intermediate in fatty acid metabolism; seen in elevated levels in cases of vitamin B12 deficiency. Note that methylmalonate is not methyl malonate, which is the dimethyl ester of malonate. Synonym(s): isosuccinic acidmethylmalonic acid A dicarboxylic acid intermediate in fatty acid metabolism, and a C-methylated derivative of malonate, which is increased in vitamin B12 and/or folate deficiency. Ref range • Serum, MA, 80–300 nmol/L; homocysteine, 8–20 µmol/L. • Urine, MA < 3.6 mmol/mol creatinine. Specimen Serum, random urine. Method GC/MS, HPLCmethylmalonic acid Isosuccinic acid An intermediate in fatty acid metabolism, which is ↑ in vitamin B12 and/or folate deficiency |