methylhistidine
methylhistidine
A methylated histidine derivative found in muscle, released in the circulation and then the urine by myofibrillary breakdown. Urine methylhistidine levels reflect rate of muscle protein turnover; urinary 1-methylhistidine levels may also be a surrogate indicator of a person’s meat consumption.Ref range
• 100–500 µmol/L, < 1 month of age.
• 100–1200 µmol/L, < 2 years.
• 170–1800 µmol/L > age 2.
Specimen
24-hour urine.
Method
HPLC.