amniotic band disruption sequence syndrome

amniotic band disruption sequence syndrome

(am?ne-ot'ik) Any of several fetal malformations associated with multiple fibrous strands of amnion that appear to develop or entangle fetal parts in utero. The disrupted sequence leads to structural malformations and deformations and disruption of function. The defects include limb defects and amputations; abnormal dermal ridge patterns; simian creases; clubbed feet; craniofacial defects, including cleft lip and palate; and visceral defects such as gastroschisis and omphalocele. Failure to understand the cause of this condition can lead to misdiagnosis and inappropriate family and genetic counseling. See: multiple malformation syndrome