maternal age effect

The adverse impact that increased age in the mother has on obstetric events: increased complication rate; increased foetal defects, due to various effects of ageing on the uterus and eggs); and increased frequency of non-disjunctional chromosomal events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15.
Maternal age and chromosome defects
[Age—Frequency of trisomy 21 (Down syndrom)—Frequency of other defects]
▪ <20—1/1900—1/526
▪ 25—1/1200—1/476
▪ 30—1/885—1/384
▪ 35—1/365—1/178
▪ 40—1/109—1/63
▪ 45—1/32—1/18
▪ 49—1/12—1/7

maternal age effect

The adverse impact that ↑ age has on obstetric events: ↑ complication rate, ↑ fetal defects–possibly due to an unknown effect of aging on the uterus and eggs; ↑ frequency of non-disjunctional events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15. See Elderly primigravida. Cf Paternal age. Maternal age & chromosome defects
Age Trisomy 21 Others <20 1/1900 1/526 25 1/1200 1/476 30 1/885 1/384 35 1/365 1/178 40 1/109 1/63 45 1/32 1/18 49 1/12 1/7

单词	maternal age effect
释义	maternal age effect maternal age effect The adverse impact that increased age in the mother has on obstetric events: increased complication rate; increased foetal defects, due to various effects of ageing on the uterus and eggs); and increased frequency of non-disjunctional chromosomal events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15. Maternal age and chromosome defects [Age—Frequency of trisomy 21 (Down syndrom)—Frequency of other defects] ▪ <20—1/1900—1/526 ▪ 25—1/1200—1/476 ▪ 30—1/885—1/384 ▪ 35—1/365—1/178 ▪ 40—1/109—1/63 ▪ 45—1/32—1/18 ▪ 49—1/12—1/7 maternal age effect The adverse impact that ↑ age has on obstetric events: ↑ complication rate, ↑ fetal defects–possibly due to an unknown effect of aging on the uterus and eggs; ↑ frequency of non-disjunctional events in Down syndrome and other aneuploidies, as well as Prader-Willi syndrome, in which there is uniparental disomy of chromosome 15. See Elderly primigravida. Cf Paternal age. Maternal age & chromosome defects Age Trisomy 21 Others <20 1/1900 1/526 25 1/1200 1/476 30 1/885 1/384 35 1/365 1/178 40 1/109 1/63 45 1/32 1/18 49 1/12 1/7
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