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单词 metaplasia
释义

metaplasia


met·a·pla·sia

M0248600 (mĕt′ə-plā′zhə)n.1. Normal transformation of tissue from one type to another, as in the ossification of cartilage to form bone.2. Transformation of cells from a normal to an abnormal state.
met′a·plas′tic (-plăs′tĭk) adj.

metaplasia

(ˌmɛtəˈpleɪzɪə) n (Physiology) the transformation of one kind of tissue into a different kind

met•a•pla•sia

(ˌmɛt əˈpleɪ ʒə, -ʒi ə)

n. the transformation of one type of cellular tissue into another. met`a•plas′tic (-ˈplæs tɪk) adj.
Translations

Metaplasia


metaplasia

[¦med·ə′plā·zhə] (pathology) Transformation of one form of tissue to another.

Metaplasia

 

(1) A permanent transformation of one variety of tissue into another that differs from it morphologically and functionally but preserves its basic species affiliation.

In animals and man, metaplasia is seen only in epithelial and connective tissues, such as in the transformation of cylindrical mucosal epithelium (respiratory, digestive, uterine) into flat, multilayered, cornifying epithelium similar to epidermis, or in the transformation of fibrous connective tissue into fatty, cartilaginous, or bony tissue. Other examples include the ossification of connective-tissue cicatricial adhesions or of the capsules around caseous tubercular foci.

A distinction is made between direct metaplasia, in which one tissue is transformed into another by means of a change in its structural elements, such as the transformation of fibrocytes into osteocytes, and indirect metaplasia, in which the development of new tissue is accomplished by the proliferation of undifferentiated cells, which only later differentiate. Indirect metaplasia most often occurs with regeneration.

The causes of metaplasia are changes in the surrounding medium and in the state of the body tissues (prolonged inflammatory processes, infectious diseases, avitaminosis A, diseases of the hematopoietic organs, hormonal shifts). Metaplasia disrupts normal tissue function and makes possible a subsequent transformation into a rudimentary tumor (anaplasia). The range of phenomena embraced by the concept of metaplasia is strictly defined by some histologists, who include only changes in differentiation on the cellular level (transformation of iris cells into lens; conversion of cells of pigmented retinal epithelium into neural retina, accompanying regeneration of the eye in adult newts).

REFERENCES

Eliseev, V. G. SoediniteVnaia tkan’ Gistofiziologicheskie ocherki. Moscow, 1961.
Metaplaziia tkanei. Moscow, 1970. (Collection of articles.)
Strukov, A. I. Patologicheskaia anatomiia, 2nd ed. Moscow, 1971.
(2) Metaplasia, or more commonly in English, metaplasis, is the period of the developmental prime in individual organisms (sexual maturity) or in the history of a group of organisms (expressed in intensive variability and abundance of individuals).

metaplasia


metaplasia

 [met″ah-pla´zhah] the change in the type of adult cells in a tissue to a form abnormal for that tissue. adj., adj metaplas´tic.agnogenic myeloid metaplasia the primary or idiopathic form of myeloid metaplasia, which is often accompanied by myelofibrosis; it is considered one of the myeloproliferative disorders" >myeloproliferative disorders. Called also aleukemic or nonleukemic myelosis.myeloid metaplasia the occurrence of myeloid tissue in extramedullary sites; specifically, a syndrome characterized by splenomegaly, anemia, nucleated erythrocytes and immature granulocytes in the circulating blood, and extramedullary hematopoiesis in the liver and spleen. The primary form is called agnogenic myeloid metaplasia. The secondary or symptomatic form may be associated with various diseases, including carcinomatosis, tuberculosis, leukemia, and polycythemia vera.

met·a·pla·si·a

(met'ă-plā'zē-ă), Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia. Synonym(s): metaplasis (2) [G. metaplasis, transformation]

metaplasia

(mĕt′ə-plā′zhə)n.1. Normal transformation of tissue from one type to another, as in the ossification of cartilage to form bone.2. Transformation of cells from a normal to an abnormal state.
met′a·plas′tic (-plăs′tĭk) adj.

metaplasia

The conversion of one type of adult tissue and/or cells—most commonly epithelia—into another; e.g., squamous metaplasia, in which non-keratinised squamous epithelium replaces ciliated columnar cells in the bronchi of smokers.
Metaplasia types
• Intestinal metaplasia—occurs in the stomach, especially in stomachs that later develop adenocarcinoma. 
• Paneth cell metaplasia and enterochromaffin cell metaplasia—occur in the gallbladder, and are associated with adenocarcinoma of same. 
• Squamous metaplasia—the transformation of glandular or ciliated epithelium to stratified sqamous epithelium. In SM of the upper respiratory tract, squamous epithelium replaces ciliated columnar epithelium; this event, particularly common in smokers, feeds the controversy that this metaplasia may represent a dysplastic process with premalignant potential. Squamous metaplasia of the endocervix is not associated with malignancy. 
• Tubal metaplasia of the endometrium—i.e., replacement of the normal endometrial glands with ciliated (fallopian) tubal cells—may occur in endometrial polyps, mild adenomatous hyperplasia and in senile endometrium, but is rarely (and then only coincidentally) associated with malignancy.

met·a·pla·si·a

(met'ă-plā'zē-ă) Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia. [G. metaplasis, transformation]

metaplasia

An abnormal change in the character or structure of a tissue as a result of changes in the constituent cells. Metaplasia often involves a change of cells to a less specialized form and may be a prelude to cancer.

metaplasia

the transformation of a tissue to another form.

met·a·pla·si·a

(met'ă-plā'zē-ă) Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia. [G. metaplasis, transformation]

Patient discussion about metaplasia

Q. what is metaplasia i had 2 surgeries in my left breast for some cyst they found metaplasia in the biopsyA. from what i remember while reading on the subject- cells can go through different changes. one of them is metaplasia- change of form. our body is amazingly flexible, and under stress cells can change form and function. like if you have continues heartburns, cells in your esophagus will change to cells similar to the stomach and start excreting anti acid materials. finding that on a biopsy means the cells in the cyst changed function.

Q. what is fragments of endocervical glandular mucosa with inflammation and squamous metaplasia fragments of endocervical glandular mucosaA. It means that part of the mucose on the cervix area has changes from a certain kind of mucose cells to another, and that there is a bit of an inflammation around it. This should be brought to the knowledge of a gynecologist and be monitored by him/her.

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