单词 | neuroleptic malignant syndrome |
释义 | neuroleptic malignant syndromeneuroleptic malignant syndromeneuroleptic[noor″o-lep´tik]neu·ro·lep·tic ma·lig·nant syn·dromeneuroleptic malignant syndromeNeurology A disorder seen in those receiving antipsychotics–eg, haloperidol, major tranquilizers, and other agents–eg, phenothiazines, reserpine, butyrophenone, an effect attributed to dopamine blockade in the basal ganglia and hypothalamus; NMS may also be associated with anesthesia, affecting +– 1:50,000 Pts exposed to inhalation anesthesia, most commonly in young ♂, transiently weakened by exhaustion, dehydration Clinical Fever ≥ 41ºC, extrapyramidal Sx–eg, rigidity, involuntary movements, facial dyskinesia, skeletal muscle hypertonicity, loss of consciousness, autonomic lability–pallor, sweating, tachycardia, arrhythmia, transient HTN which, if severe, may cause renal failure Mortality 20-30%, often between days 3-30, usually from renal failure Treatment Bromocriptine or dantrolene may shorten clinical disease.neu·ro·lep·tic ma·lig·nant syn·drome(nūr'ō-lep'tik mă-lig'nănt sin'drōm)neuroleptic malignant syndromeA rare and sometimes fatal disorder related to the use of any NEUROLEPTIC drug in any dosage. It features high fever, sweating, severe rigidity of muscles, wide swings of blood pressure, incontinence, confusion and coma. |
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