neurofibrillary tangle

neu·ro·fi·bril·la·ry tan·gle

intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in patients with Alzheimer disease.

neurofibrillary tangle

A characteristic histologic finding in the perikaryon of large cortical neurones of patients with Alzheimer’s disease, which consists of fibrilised protein derived from microtubule-associated protein tau. The number of NFTs loosely correlates with the severity of dementia.

DiffDx
Down’s syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults (confined to the hippocampus).

neurofibrillary tangle

Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. See Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques.

Neurofibrillary tangle

—Twisted masses of protein inside nerve cells that develop in the brains of people with AD.Mentioned in: Alzheimer's Disease

单词	neurofibrillary tangle
释义	neurofibrillary tangle neurofibrillary tangle [‚nu̇·rō‚fīb·rə‚ler·ē ′taŋ·gəl] (pathology) The accumulation of twisted protein filaments (neurofibrils) within neurons of the cerebral cortex; a characteristic pathological feature found in the brains of Alzheimer's disease patients. neurofibrillary tangle neu·ro·fi·bril·la·ry tan·gle intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in patients with Alzheimer disease. neurofibrillary tangle A characteristic histologic finding in the perikaryon of large cortical neurones of patients with Alzheimer’s disease, which consists of fibrilised protein derived from microtubule-associated protein tau. The number of NFTs loosely correlates with the severity of dementia. DiffDx Down’s syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults (confined to the hippocampus). neurofibrillary tangle Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. See Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques. Neurofibrillary tangle —Twisted masses of protein inside nerve cells that develop in the brains of people with AD.Mentioned in: Alzheimer's Disease
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