osteoclast-like giant cell
osteoclast-like giant cell
A multinucleated giant cell with abundant eosinophilic, finely granular or homogeneous cytoplasm containing up to 100 uniform oval nuclei, each measuring 5–7 µm with scattered small nucleoli and peripheral chromatin.DiffDx
Osteoclast-like giant cells are often scattered among plump spindled mononuclear cells and may occur in benign and malignant conditions—e.g., fibrous histiocytoma, Langerhan’s cell histiocytosis, in the mural nodules of mucin-producing ovarian and liver cancer, Hodgkin lymphoma, tumoural calcinosis.