neuritic plaque

neu·rit·ic plaque

a spheric mass primarily composed of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak) A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.

单词	neuritic plaque
释义	neuritic plaque neuritic plaque [nu̇‚rid·ik ′plak] (pathology) Abnormal clumps of degenerating neurons surrounding a core of amyloid protein; a characteristic pathological feature found in the brains of Alzheimer's disease patients. neuritic plaque neu·rit·ic plaque a spheric mass primarily composed of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease. senile plaque A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease. se·nile plaque (sen'il plak) A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease. Synonym(s): neuritic plaque.
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