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acetylcholinesteraseenUK
a·ce·tyl·cho·li·nes·ter·ase A0051800 (ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz′)n. An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of acetylcholine.acetylcholinesterase (əˈsiːtaɪlˌkəʊliːnˈɛstərˌeɪz; ˈæsɪtaɪl-) n (Biochemistry) an enzyme in nerve cells that is responsible for the destruction of acetylcholine and thus for switching off excitation of the nervea•ce•tyl•cho•lin•es•ter•ase (əˌsit lˌkoʊ ləˈnɛs təˌreɪs, -ˌreɪz, əˌsɛt-, ˌæs ɪ tl-)
n. an enzyme that counteracts the effects of acetylcholine by hydrolyzing it to choline and acetate. [1945–50] acetylcholinesteraseenUK
acetylcholinesterase[ə‚sed·əl·kō·lən′es·tər‚ās] (biochemistry) An enzyme found in excitable membranes that inactivates acetylcholine. acetylcholinesteraseenUK
acetylcholinesterase [as″ĕ-til-ko″lin-es´ter-ās] an enzyme present in nervous tissue, muscle, and red blood cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid. This enzyme is present throughout the body, but is particularly important at the junction" >myoneural junction, where the nerve fibers terminate. Acetylcholine is released when a nerve impulse reaches a myoneural junction. It diffuses across the synaptic cleft and binds to cholinergic receptors on the muscle fibers, causing them to contract. cholinesterase splits acetylcholine into its components, thus stopping stimulation of the muscle fibers. The end products of the metabolism of acetylcholine are taken up by nerve fibers and resynthesized into acetylcholine. The drugs neostigmine, physostigmine, and pyridostigmine inhibit acetylcholinesterase and are used to treat myasthenia gravis, a disease in which the cholinergic receptors are attacked by autoantibodies. The drug extends the effect of acetylcholine on the muscle fiber. Called also true cholinesterasea·ce·tyl·cho·lin·es·ter·ase (a-sĕ'til-kō'lin-es'ter-ās), [MIM*100740] The cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (for example, motor endplates and autonomic ganglia). Synonym(s): choline esterase I, "e"-type cholinesterase, specific cholinesterase, true cholinesteraseacetylcholinesterase (ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz′)n. An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of acetylcholine.Acetylcholinesterase A hydrolase in the membrane of postsynaptic cells which metabolises acetylcholine into choline and acetic acid in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impulse.
Location CNS, red cells, motor endplatesacetylcholinesterase Neurophysiology A hydrolase that metabolizes acetylcholine to acetyl and choline in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impule; acetylcholinesterase is found in the CNS, RBCs, motor endplatesa·ce·tyl·cho·lin·es·ter·ase (AChE) (as'ĕ-til-kō'lin-es'tĕr-ās) One of a family of enzymes capable of catalyzing the hydrolysis of acetylcholine. acetylcholinesterase An ENZYME that rapidly inactivates ACETYLCHOLINE by breaking it down to acetic acid and choline. Also known as cholinesterase.acetylcholinesterase the enzyme present in the synaptic cleft that destroys acetylcholine (see END PLATE).AcetylcholinesteraseAn enzyme that breaks down acetylcholine.Mentioned in: Insecticide Poisoningacetylcholinesterase An enzyme that degrades and inactivates acetylcholine. This compound is mainly found in neurons and at neuromuscular junctions. Drugs that inhibit this enzyme (e.g. diisopropyl fluorophosphate, physostigmine, edrophonium, echothiophate, DFP) can be used in the diagnosis and possible treatment of myasthenia gravis as well as certain forms of esotropia and glaucoma. Syn. specific cholinesterase. See anticholinesterase drugs.a·ce·tyl·cho·lin·es·ter·ase (as'ĕ-til-kō'lin-es'tĕr-ās) [MIM*100740] Cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (e.g., motor endplates and autonomic ganglia). AcronymsSeeAChESThesaurusSeeache |