lupoid hepatitis
lu·poid hep·a·ti·tis
autoimmune hepatitis
A multisystem disorder that primarily affects women of all ages, coexists with other liver diseases (e.g., chronic viral hepatitis) and is triggered by viral infections (e.g., HAV) and chemicals (e.g., minocycline).Aetiology
Linked to circulating autoantibodies, and may be linked to other autoimmune disorders—e.g., thyroiditis, diabetes, ulcerative colitis, Coombs-positive haemolytic anaemia, proliferative glomerulonephritis, Sjögren syndrome.
Lab
Increased: IgG; anti-nuclear, anti-smooth muscle, anti-LKM, anti-mitochondrial antibodies; and anti-phospholipid antibodies; elevated
LFTs.
Management
Daily prednisone.
Types of autoimmune hepatitis
• Type 1—Most common form of AIH in North America; 80% are women; may have increased anti-smooth muscle antibodies, anti-nuclear antibodies, anti-actin, and often have a marked increase in immune globulins.
• Type 2—Less common than type 1; affects children ages 2 to 14, 90% female; typically have anti-LKM antibodies.
• Type 3—Similar to type 1; 90% occur in younger (age 30–50) females.