BCL10
BCL10
A gene on chromosome 1p22 that encodes a protein which contains a caspase recruitment domain (CARD); it induces apoptosis, activates NF-kappaB and interacts with other CARD domain proteins (e.g., CARD9, 10, 11 and 14), which are thought to act as upstream regulators in NF-kappaB signalling.Molecular pathology
BCL10 protein product forms a complex with MALT1, a protein encoded by a gene that is translocated in MALT lymphoma and together activate NF-kappaB; deregulation of either BCL10 or MALT1 may lead to MALToma.