Lucentis
ranibizumab
(ran-i-bi-zoo-mab) ranibizumab,Lucentis
(trade name)Classification
Therapeutic: ocular agentsPharmacologic: monoclonal antibodies
Indications
Action
Therapeutic effects
Pharmacokinetics
Time/action profile
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
intravitreal | unknown | after injection | 1 mo |
Contraindications/Precautions
Adverse Reactions/Side Effects
Ear, Eye, Nose, Throat
- conjunctival hemorrhage (most frequent)
- eye pain (most frequent)
- ↑ intraocular pressure (most frequent)
- intraocular inflammation (most frequent)
- vitreal floaters (most frequent)
- endophthalmitis
- retinal detachment
Cardiovascular
- arterial thromboembolic events (life-threatening)
Interactions
Drug-Drug interaction
↑ risk of serious intraocular inflammation with verteporfin.Route/Dosage
Macular Degeneration
Macular Edema Following Retinal Vein Occlusion
Diabetic Macular Edema
Availability
Nursing implications
Nursing assessment
- Assess eye for signs of infection frequently during week following injection.
- Check perfusion of optic nerve head immediately after injection, use tonometry to measure intraocular pressure prior to and 60 min following the injection.
Potential Nursing Diagnoses
Disturbed sensory perception (Indications)Implementation
- Do not administer solutions that are discolored or contain particulate matter. Attach threaded plastic threader rod to the rubber stopper inside barrel of syringe. Do not pull back on plunger.
- Adequate analgesia and a broad-spectrum antibiotic should be given prior to injection.
- Intravitreal: For ophthalmic intravitreal injection only. Withdraw vial contents through a 5–micron gauge filter needle attached to a 1–cc tuberculin syringe. Discard filter needle after withdrawal. Replace filter needle with sterile 30–gauge x 1/2-inch needle for intravitreal injection. Expel contents until plunger tip is aligned with line marking 0.05 mL on syringe Each vial should be used for only one eye. If contralateral eye requires treatment, use new vial and equipment. Refrigerate solution and protect from light; do not freeze.
Patient/Family Teaching
- Advise patient to notify ophthalmologist immediately if eye becomes red, sensitive to light, painful, or develops a change in vision.
Evaluation/Desired Outcomes
- Slowing of vision loss.