| 单词 | melanocortin 4 receptor |
| 释义 | melanocortin 4 receptorMC4RA gene on chromosome 18q22 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase and expressed in the brain, placenta and gut.Molecular pathology Defects in MC4R are linked to obesity. melanocortin 4 receptor (MC4R)A cell receptor that is strongly stimulated by the alpha melanocyte-stimulating hormone-a peptide that produces a sense of fullness after eating. Mutations of the gene that codes for MC4R are commonly associated with severe uncontrollable overeating and pathological obesity. Such mutations can be found in nearly 6 per cent of people with a life-long history of obesity. |
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