megaoesophagus

A classic late complication of Chagas’ disease, consisting of marked dilation of the oesophagus, that develops 2–20 years after infection by Trypanosoma cruzi. The change evokes dysphagia when 50% of the oesophagus’ ganglion cells are destroyed, and frank megaoesophagus when 90% are destroyed, possibly the combined result of toxic effects of the parasite and chronic inflammation and connective tissue response.

Clinical findings
Dysphagia, aspiration pneumonia, lung abscess, oesophageal carcinoma.

单词	megaoesophagus
释义	megaoesophagus megaoesophagus A classic late complication of Chagas’ disease, consisting of marked dilation of the oesophagus, that develops 2–20 years after infection by Trypanosoma cruzi. The change evokes dysphagia when 50% of the oesophagus’ ganglion cells are destroyed, and frank megaoesophagus when 90% are destroyed, possibly the combined result of toxic effects of the parasite and chronic inflammation and connective tissue response. Clinical findings Dysphagia, aspiration pneumonia, lung abscess, oesophageal carcinoma.
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