| 释义 |
Nalfon
Thesaurus| Noun | 1. | Nalfon - a nonsteroidal anti-inflammatory drug (trade name Nalfon) used in the treatment of arthritis and other painful inflammatory disordersfenoprofen, fenoprofen calciumnonsteroidal anti-inflammatory, nonsteroidal anti-inflammatory drug, NSAID - an anti-inflammatory drug that does not contain steroids; "NSAIDs inhibit the activity of both Cox-1 and Cox-2 enzymes"propanoic acid, propionic acid - a liquid fatty acid found in milk and sweat and in fuel distillatesbrand, brand name, marque, trade name - a name given to a product or service |
Nalfon
Nalfon [nal´fon] trademark for a preparation of fenoprofen calcium, a nonsteroidal antiinflammatory drug.fenoprofen (fen-oh-proe-fen) fenoprofen, Nalfon (trade name) Classification Therapeutic: nonopioid analgesics
Pharmacologic: propionic acid derivatives
Pregnancy Category: C (first and second trimester)
Pregnancy Category: D (third trimester)
IndicationsRheumatoid arthritis.Osteoarthritis.Mild to moderate pain.ActionInhibits prostaglandin synthesis.Therapeutic effectsSuppression of pain and inflammation.PharmacokineticsAbsorption: Well absorbed from the GI tract.Distribution: Enters breast milk in low concentrations.Protein Binding: >99%.Metabolism and Excretion: Mostly metabolized by the liver. 2–5% excreted unchanged by the kidneys.Half-life: 3 hr.Time/action profile | ROUTE | ONSET | PEAK | DURATION | | PO (analgesic activity) | 15–30 min | 1–2 hr | 4–6 hr | | PO (anti-inflammatory activity) | several days | 2–3 wk | unknown |
Contraindications/PrecautionsContraindicated in: Hypersensitivity to fenoprofen, aspirin, or other NSAIDS; Active GI bleeding or ulcer disease; Severe renal dysfunction; Perioperative pain in setting of coronary artery bypass surgery.Use Cautiously in: Cardiovascular, renal, or hepatic disease; History of ulcer disease; Obstetric: Not recommended for use during third trimester; Geriatric: ↑ risk of adverse events; Lactation / Pediatric: Safety not established.Adverse Reactions/Side EffectsCentral nervous system- confusion
- dizziness
- drowsiness
- headache
Ear, Eye, Nose, Throat- blurred vision
- hearing loss
- tinnitus
CardiovascularGastrointestinal- GI bleeding (life-threatening)
- hepatitis (life-threatening)
- dyspepsia (most frequent)
- abdominal pain
- constipation
- diarrhea
- discomfort
- nausea
- vomiting
Genitourinary- cystitis
- dysuria
- hematuria
- renal failure
DermatologicHematologicNeurologicMiscellaneous- allergic reactions including anaphylaxis (life-threatening)
InteractionsDrug-Drug interactionConcurrent use with aspirin or antacids may ↓ effectiveness.Additive adverse GI effects with aspirin, other NSAIDs, potassium supplements, corticosteroids, or alcohol.May ↓ the effectiveness of diuretics or antihypertensives.May ↑ serum lithium levels and ↑ the risk of toxicity.↑ the risk of toxicity from methotrexate.↑ risk of bleeding with cefotetan, heparin, thrombolytic agents, antiplatelet agents, or warfarin.↑ risk of adverse hematologic reactions with antineoplastics or radiation therapy.Phenobarbital may ↑ metabolism and ↓ effectiveness of fenoprofen.May ↑ the risk of nephrotoxicity withcyclosporine.↑ bleeding risk with anise, arnica, chamomile, clove, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.Route/DosageRheumatoid Arthritis/OsteoarthritisOral (Adults) 400–600 mg 3–4 times daily (not to exceed 3.2 g/day).Mild-to-Moderate PainOral (Adults) 200 mg q 4–6 hr.Availability (generic available)Capsules: 200 mg, 400 mg Tablets: 600 mg Nursing implicationsNursing assessment- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Monitor for rhinitis, asthma, and urticaria.
- Arthritis: Assess pain and range of movement before and 1–2 hr after administration.
- Pain: Assess pain (type, location, and intensity) before and 1–2 hr after administration.
- Lab Test Considerations: May cause prolonged bleeding time.
- May cause ↓ hemoglobin, hematocrit, leukocyte, and platelet counts.
- Monitor liver function tests periodically during long-term therapy. May cause ↑ serum alkaline phosphatase, LDH, AST, and ALT concentrations.
- Monitor BUN, serum creatinine, and electrolytes periodically during therapy. May cause ↑ BUN and serum creatinine.
Potential Nursing DiagnosesAcute pain (Indications)
Impaired physical mobility (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)
Implementation- Administration in higher than recommended doses does not provide increased effectiveness but may cause increased side effects.
- Coadministration with opioid analgesics may have additive analgesic effects and may permit lower opioid doses.
- Oral: For rapid initial effect, administer 30 min before or 2 hr after meals. Administer after meals or with food to minimize gastric irritation.
Patient/Family Teaching- Advise patient to take this medication with a full glass of water and to remain in an upright position for 15–30 min after administration.
- Instruct patient to take medication as directed. Take missed doses as soon as remembered, but not if almost time for next dose. Do not double doses.
- May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
- Caution patient to avoid concurrent use of alcohol, aspirin, acetaminophen, other NSAIDs, or other OTC or herbal products without consulting health care professional.
- Instruct patient to notify health care professional of medication regimen before treatment or surgery.
- Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs.
Evaluation/Desired Outcomes- Decrease in severity of pain.
- Improved joint mobility. Partial arthritic relief is usually seen within a few days, but maximum effects may require 2–3 wk of continuous therapy. Patients who do not respond to one NSAID may respond to another.
Nalfon® Fenoprofen, see there. Nalfon
Synonyms for Nalfonnoun a nonsteroidal anti-inflammatory drug (trade name Nalfon) used in the treatment of arthritis and other painful inflammatory disordersSynonyms- fenoprofen
- fenoprofen calcium
Related Words- nonsteroidal anti-inflammatory
- nonsteroidal anti-inflammatory drug
- NSAID
- propanoic acid
- propionic acid
- brand
- brand name
- marque
- trade name
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