| Acronym | Definition |
|---|
| LOTO➣Leader of the Opposition |
| LOTO➣Lake of the Ozarks (Missouri) |
| LOTO➣Laughing on the Outside |
| LOTO➣Lock Out Tag Out (safety) |
| LOTO➣Landscape Opportunities for Territorial Organization (Italy) |
| LOTO➣Lemmings of the Outback (online gaming community) |