New Zealand mouse

Either of two strains—New Zealand black (NZB) and white (NZW)—of inbred mice, used to study autoimmunity.
NZW mice are asymptomatic; NZB mice develop autoimmune haemolytic anaemia, extramedullary hematopoiesis, low titres of antinuclear antibodies, spontaneously activated B cells, defective T cells and defects in DNA repair. When NZW are crossed with NZB, the progeny develop an autoimmune syndrome with severe immune complex disease , glomerulonephritis, LE cells, and high titers of anti-nuclear antibodies; thus the F1 generation of NZB/NZW mice serves as an animal model for autoimmune disease and systemic lupus erythematosus.

单词	new zealand mouse
释义	New Zealand mouse New Zealand mouse Either of two strains—New Zealand black (NZB) and white (NZW)—of inbred mice, used to study autoimmunity. NZW mice are asymptomatic; NZB mice develop autoimmune haemolytic anaemia, extramedullary hematopoiesis, low titres of antinuclear antibodies, spontaneously activated B cells, defective T cells and defects in DNA repair. When NZW are crossed with NZB, the progeny develop an autoimmune syndrome with severe immune complex disease , glomerulonephritis, LE cells, and high titers of anti-nuclear antibodies; thus the F1 generation of NZB/NZW mice serves as an animal model for autoimmune disease and systemic lupus erythematosus.
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