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nordihydroguaiaretic acid
nordihydroguaiaretic acid[¦nȯr·dī¦hī·drō¦gwī·ə¦red·ik ′as·əd] (organic chemistry) C18H22O4 A crystalline compound with a melting point of 184-185°C; soluble in alcohols, ether, acetone, glycerol, and propyleneglycol; used as an antioxidant in fats and oils. Abbreviated NDGA. nordihydroguaiaretic acid
nordihydroguaiaretic acid A relatively nontoxic phenolic quinone obtained from the oily resin of the evergreen shrub (chaparral) or creosote bush (Larrea divaricata, Covillea tridentata). Alternative pharmacology NDGA appears to have a broad spectrum of anticancer properties, the efficacy of which is attributed to NDGA’s antioxidant activity, its virtually complete inhibition of anaerobic glycolysis and its inhibition of DNA synthesis; NDGA may be useful in treating choriocarcinoma, gastrointestinal tumours, gliomas of the brain, leukaemia, lymphoma and melanoma.See NDGA See NDGA |