释义 |
loss of heterozygosity
loss of heterozygosity[¦lȯs əv ‚hed·e·rō·zī′gäs·əd·ē] (genetics) In a heterozygote, the loss of one of the two alleles at one or more loci in a cell lineage or cancer cell population due to chromosome loss, deletion, or mitotic crossing-over. Abbreviated LOH. loss of heterozygosity
loss of heterozygosity adjective Referring to a mutation that results in the loss of allelic uniqueness, often defined as a ≥ 40% increase in signal intensity of allelic signal.AcronymsSeeLOH |