mucosal immune system

mucosal immune system

Clusters of lymphoid cells beneath the mucosal endothelium of the gastrointestinal, respiratory, and genitourinary tracts that help protect the body from inhaled, consumed, or sexually transmitted infections. The system has two parts: organized and diffuse. The organized part (the mucosal-associated lymphoid tissue of the gastrointestinal and respiratory tracts) is composed of nodules containing lymphocytes and macrophages that are activated by ingested or inhaled microorganisms. The diffuse part is composed of loose clusters of macrophages and mature B and T lymphocytes found within the folds of the intestinal walls. The B cells secrete antibodies, primarily immunoglobulin A; the T cells directly lyse microorganisms.

The mucosal immune system is augmented by the presence of normal microflora; by peristalsis and cilia, which move mucus outward; and by various chemicals, such as gastric acid and pancreatic enzymes, which destroy pathogens. Normally all of these components must be functioning to prevent infection.