mucopolysaccharidosis II

An X-linked recessive mucopolysaccharidosis caused by a defect in IDS on chromosome Xq28, which encodes iduronate-2 sulfatase, which is responsible for lysosomal degradation of heparan sulfate and dermatan sulfate.

Clinical findings
Early-onset form, type A appears by age 2—large skull, coarse facies, profound mental retardation, spasticity, joint stiffness, aggressive behaviour; late-onset type B results in much milder symptoms.

mucopolysaccharidosis II

Hunter syndrome, iduronate 2-sulfatase deficiency Metabolic disorders An X-R–♀ carriers, ♂ with disease mucopolysaccharidosis due to a defect in iduronosulfate sulfatase, resulting in tissue accumulation of chondroitin sulfate B and heparan sulfate Clinical Early onset form, type A appears by age 2–large skull, coarse facies, profound mental retardation, spasticity, joint stiffness, aggressive behavior; late onset type B causes much milder Sx. See Mucopolysaccharidosis.

mucopolysaccharidosis II

Mucopolysaccharidosis due to a deficiency of the enzyme l-iduronosulfate sulfatase. Clinically, there are retinal degeneration without corneal clouding, mental retardation, joint stiffness, skeletal dysplasia, cardiac lesions, and deafness. Synonym: Hunter's diseaseSee also: mucopolysaccharidosis

单词	mucopolysaccharidosis ii
释义	DictionarySeemucopolysaccharidosisEncyclopediaSeeHunter syndrome mucopolysaccharidosis II mucopolysaccharidosis II An X-linked recessive mucopolysaccharidosis caused by a defect in IDS on chromosome Xq28, which encodes iduronate-2 sulfatase, which is responsible for lysosomal degradation of heparan sulfate and dermatan sulfate. Clinical findings Early-onset form, type A appears by age 2—large skull, coarse facies, profound mental retardation, spasticity, joint stiffness, aggressive behaviour; late-onset type B results in much milder symptoms. mucopolysaccharidosis II Hunter syndrome, iduronate 2-sulfatase deficiency Metabolic disorders An X-R–♀ carriers, ♂ with disease mucopolysaccharidosis due to a defect in iduronosulfate sulfatase, resulting in tissue accumulation of chondroitin sulfate B and heparan sulfate Clinical Early onset form, type A appears by age 2–large skull, coarse facies, profound mental retardation, spasticity, joint stiffness, aggressive behavior; late onset type B causes much milder Sx. See Mucopolysaccharidosis. mucopolysaccharidosis II Mucopolysaccharidosis due to a deficiency of the enzyme l-iduronosulfate sulfatase. Clinically, there are retinal degeneration without corneal clouding, mental retardation, joint stiffness, skeletal dysplasia, cardiac lesions, and deafness. Synonym: Hunter's diseaseSee also: mucopolysaccharidosis
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