malignant granuloma

le·thal mid·line gran·u·lo·ma

1. destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; a form of lymphoma in most cases. 2. obsolete term for polymorphic reticulosis. Synonym(s): granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma

lethal midline granuloma

The term is now retired and of historic interest. Lethal midline granuloma was best considered a clinical syndrome rather than a specific histologic lesion, and described as a destructive lesion of the upper respiratory tract—nose, nasopharynx, palate and midface. It was either idiopathic or secondary to lymphoma, malignant histiocytosis or Wegener’s granulomatosis. Many of the lesions formerly designated as lethal midline granoma would now be called angiocentric lymphoma and angiocentric immunoproliferative lesions.

mid·line le·thal gran·u·lo·ma

(mid'līn lē'thăl gran'yū-lō'mă) Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit, and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a hypersensitivity response to an unidentified antigen in most cases. The prognosis is poor, despite radiotherapy.
Synonym(s): malignant granuloma.

granuloma

(gran?yu-lo'ma ) (gran?yu-lo'ma-ta) plural.granulomasplural.granulomata [ granulo- + -oma] An inflammatory response that results when macrophages are unable to destroy foreign substances that have entered or invaded body tissues. Large numbers of macrophages are drawn to the affected area over 7 to 10 days, surround the target, and enclose it. They in turn are surrounded by polymorphonuclear leukocytes, other immune cells, and fibroblasts. Granulomas are common in many conditions, including leprosy, tuberculosis, cat scratch disease, some fungal infections, and foreign body reactions, e.g., reactions to sutures. granulomatous (gran?yu-lo'ma-tus), adjective See: giant cell; tuberculosis; Wegener granulomatosis

GRANULOMA ANNULARE

granuloma annulare

A circular rash with a raised red border, usually found on the hands, knuckles, or arms of young patients. The cause is unknown. The rash often lasts 1 or 2 years and then may disappear spontaneously. See: illustration

apical granuloma

Dental granuloma.

benign granuloma of the thyroid

A lymphadenoma of the thyroid.

coccidioidal granuloma

A chronic, generalized granuloma caused by the fungus Coccidioides immitis. See: coccidioidomycosis

dental granuloma

A granuloma developing at the tip of a tooth root, usually the result of pulpitis. It consists of a proliferating mass of chronic inflammatory tissue and possibly epithelial nests or colonies of bacteria. It may be encapsulated by fibrous tissue of the periodontal ligament. Synonym: apical granuloma; apical periodontitis

eosinophilic granuloma

A form of xanthomatosis accompanied by eosinophilia and the formation of cysts on bone.

granuloma fissuratum

A circumscribed, firm, fissured, fibrotic, benign tumor caused by chronic irritation. It may occur where hard objects such as dentures or the earpieces of glasses rub against the labioalveolar fold or the retroauricular fold. The tumor disappears when the irritating object is removed.

foreign body granuloma

Chronic inflammation around foreign bodies such as sutures, talc, splinters, or gravel. Synonym: foreign body reaction

granuloma fungoides

Mycosis fungoides.

infectious granuloma

Any infectious disease in which granulomas are formed, e.g., tuberculosis or syphilis. Granulomas are also formed in mycoses and protozoan infections.

granuloma inguinale

A granulomatous ulcerative disease in which the initial lesion commonly appears in the genital area as a painless nodule.

Etiology

This type of granuloma is caused by a short, gram-negative bacillus, Calymmatobacterium granulomatis, (“Donovan body”).

Treatment

Erythromycin, trimethoprim-sulfamethoxazole, or tetracyclines are used in treating this disease. Single-dose therapy with intramuscular ceftriaxone or oral ciprofloxacin may be effective.

granuloma iridis

A granuloma that develops on the iris.

lipoid granuloma

A granuloma that contains fatty tissue or cholesterol.

lipophagic granuloma

A granuloma in which the macrophages have phagocytosed the surrounding fat cells.

Majocchi granuloma

Majocchi disease.

malignant granuloma

Hodgkin disease.

pyogenic granuloma

See: lobular capillary hemangioma

granuloma pyogenicum

See: lobular capillary hemangioma

pyrogenic granuloma

See: lobular capillary hemangioma

swimming pool granuloma

A chronic skin infection caused by Mycobacterium marinum.

granuloma telangiectaticum

A very vascular granuloma at any site, but esp. in the nasal mucosa or pharynx.

trichophytic granuloma

Majocchi disease.

单词	malignant granuloma
释义	DictionarySeegranulomaEncyclopediaSeeGranuloma malignant granuloma le·thal mid·line gran·u·lo·ma 1. destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; a form of lymphoma in most cases. 2. obsolete term for polymorphic reticulosis. Synonym(s): granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma lethal midline granuloma The term is now retired and of historic interest. Lethal midline granuloma was best considered a clinical syndrome rather than a specific histologic lesion, and described as a destructive lesion of the upper respiratory tract—nose, nasopharynx, palate and midface. It was either idiopathic or secondary to lymphoma, malignant histiocytosis or Wegener’s granulomatosis. Many of the lesions formerly designated as lethal midline granoma would now be called angiocentric lymphoma and angiocentric immunoproliferative lesions. mid·line le·thal gran·u·lo·ma (mid'līn lē'thăl gran'yū-lō'mă) Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit, and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a hypersensitivity response to an unidentified antigen in most cases. The prognosis is poor, despite radiotherapy. Synonym(s): malignant granuloma. granuloma (gran?yu-lo'ma ) (gran?yu-lo'ma-ta) plural.granulomasplural.granulomata [ granulo- + -oma] An inflammatory response that results when macrophages are unable to destroy foreign substances that have entered or invaded body tissues. Large numbers of macrophages are drawn to the affected area over 7 to 10 days, surround the target, and enclose it. They in turn are surrounded by polymorphonuclear leukocytes, other immune cells, and fibroblasts. Granulomas are common in many conditions, including leprosy, tuberculosis, cat scratch disease, some fungal infections, and foreign body reactions, e.g., reactions to sutures. granulomatous (gran?yu-lo'ma-tus), adjective See: giant cell; tuberculosis; Wegener granulomatosisGRANULOMA ANNULARE granuloma annulare A circular rash with a raised red border, usually found on the hands, knuckles, or arms of young patients. The cause is unknown. The rash often lasts 1 or 2 years and then may disappear spontaneously. See: illustration apical granuloma Dental granuloma. benign granuloma of the thyroid A lymphadenoma of the thyroid. coccidioidal granuloma A chronic, generalized granuloma caused by the fungus Coccidioides immitis. See: coccidioidomycosis dental granuloma A granuloma developing at the tip of a tooth root, usually the result of pulpitis. It consists of a proliferating mass of chronic inflammatory tissue and possibly epithelial nests or colonies of bacteria. It may be encapsulated by fibrous tissue of the periodontal ligament. Synonym: apical granuloma; apical periodontitis eosinophilic granuloma A form of xanthomatosis accompanied by eosinophilia and the formation of cysts on bone. granuloma fissuratum A circumscribed, firm, fissured, fibrotic, benign tumor caused by chronic irritation. It may occur where hard objects such as dentures or the earpieces of glasses rub against the labioalveolar fold or the retroauricular fold. The tumor disappears when the irritating object is removed. foreign body granuloma Chronic inflammation around foreign bodies such as sutures, talc, splinters, or gravel. Synonym: foreign body reaction granuloma fungoides Mycosis fungoides. infectious granuloma Any infectious disease in which granulomas are formed, e.g., tuberculosis or syphilis. Granulomas are also formed in mycoses and protozoan infections. granuloma inguinale A granulomatous ulcerative disease in which the initial lesion commonly appears in the genital area as a painless nodule. Etiology This type of granuloma is caused by a short, gram-negative bacillus, Calymmatobacterium granulomatis, (“Donovan body”). Treatment Erythromycin, trimethoprim-sulfamethoxazole, or tetracyclines are used in treating this disease. Single-dose therapy with intramuscular ceftriaxone or oral ciprofloxacin may be effective. granuloma iridis A granuloma that develops on the iris. lipoid granuloma A granuloma that contains fatty tissue or cholesterol. lipophagic granuloma A granuloma in which the macrophages have phagocytosed the surrounding fat cells. Majocchi granuloma Majocchi disease. malignant granuloma Hodgkin disease. pyogenic granuloma See: lobular capillary hemangioma granuloma pyogenicum See: lobular capillary hemangioma pyrogenic granuloma See: lobular capillary hemangioma swimming pool granuloma A chronic skin infection caused by Mycobacterium marinum. granuloma telangiectaticum A very vascular granuloma at any site, but esp. in the nasal mucosa or pharynx. trichophytic granuloma Majocchi disease.
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