nizatidine

[nĭ-za´tĭ-dēn] a histamine H₂ receptor antagonist, used to inhibit gastric acid secretion in the treatment of gastric and duodenal ulcer, gastroesophageal reflux disease, and conditions that cause gastric hypersecretion; administered orally.

nizatidine

Apo-Nizatidine, Axid, Axid AR, Dom-Nizatidine, Gen-Nizatidine, Novo-Nizatidine, PHL-Nizatidine, PMS-Nizatidine, Zinga (UK)

Pharmacologic class: Histamine₂ (H₂)-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B

Action

Inhibits histamine action at H₂-receptor sites in gastric parietal cells, reducing gastric acid secretion and pepsin production

Availability

Capsules: 150 mg, 300 mg

Oral solution: 15 mg/ml

Tablets: 75 mg

Indications and dosages

➣ Active duodenal ulcer Adults: 300 mg P.O. daily at bedtime or 150 mg b.i.d. for up to 8 weeks

➣ Maintenance of healed duodenal ulcers

Adults and children ages 12 and older: 150 mg P.O. daily at bedtime for up to 1 year

➣ Esophagitis and associated heartburn caused by gastroesophageal reflux disease (GERD)

Adults: 150 mg P.O. b.i.d. for up to 12 weeks

➣ Active benign gastric ulcer Adults: 150 mg P.O. b.i.d. or 300 mg P.O. once daily at bedtime

➣ Erosive esophagitis; GERD

Children ages 12 and older: 150 mg P.O. b.i.d. for up to 8 weeks

Dosage adjustment

• Moderate to severe renal impairment

• Elderly patients

Contraindications

• Hypersensitivity to drug or other H₂-receptor antagonists

Precautions

Use cautiously in:

• mild renal impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 (safety and efficacy not established).

Administration

• Give with or without food.

• If patient is to take drug twice daily, give one dose in morning and one at bedtime.

Adverse reactions

CNS: dizziness, drowsiness, headache, anxiety, nervousness, insomnia, abnormal dreams, asthenia

CV: chest pain

EENT: amblyopia, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, flatulence, anorexia, dry mouth

Hematologic: anemia

Musculoskeletal: back pain, myalgia

Respiratory: cough

Skin: rash, pruritus

Other: tooth disorder, infection, fever, pain

Interactions

Drug-drug. Salicylates (high doses): increased salicylate blood level

Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase: elevated levels

Urobilinogen tests using Multistix: false-positive result

Drug-herbs. Pennyroyal: altered rate of herbal metabolite formation

Patient monitoring

• Monitor liver and renal function tests.

• Check temperature; watch for fever and other signs and symptoms of infection.

Patient teaching

• Advise patient to take once-daily dose at bedtime with or without food, or twice-daily doses in morning and at bedtime.

• Instruct patient to take exactly as prescribed. Caution him not to take other OTC drugs (especially aspirin).

• Tell patient to report signs and symptoms of infection.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

nizatidine

(nī-zăt′ĭ-dēn′)n. A histamine receptor antagonist, C₁₂H₂₁N₅O₂S₂, that inhibits the secretion of gastric acid and is used to treat duodenal and gastric ulcers and gastroesophageal reflux disease.

nizatidine

A H2-receptor antagonist used to treat peptic ulcer disease.

Adverse reactions
Diarrhoea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynaecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis.

nizatidine

Axid^® Therapeutics An H₂-receptor antagonist used to treat peptic ulcer disease Adverse reactions Diarrhea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis, etc. See Histamine receptor antagonists.

nizatidine

An H₂ RECEPTOR ANTAGONIST drug used to prevent and treat peptic ulcers. Brand names are Axid and Zinga.

单词	nizatidine
释义	nizatidine ni·zat·i·dine N5135050 (nī-zăt′ĭ-dēn′)n. A histamine receptor antagonist, C₁₂H₂₁N₅O₂S₂, that inhibits the secretion of gastric acid and is used to treat duodenal and gastric ulcers and gastroesophageal reflux disease. [ni(tro)- + alteration of (a)zo- + -tidine, histamine receptor antagonist suff.; see ranitidine.] Translations nizatidine nizatidine [nĭ-za´tĭ-dēn] a histamine H₂ receptor antagonist, used to inhibit gastric acid secretion in the treatment of gastric and duodenal ulcer, gastroesophageal reflux disease, and conditions that cause gastric hypersecretion; administered orally. nizatidine Apo-Nizatidine, Axid, Axid AR, Dom-Nizatidine, Gen-Nizatidine, Novo-Nizatidine, PHL-Nizatidine, PMS-Nizatidine, Zinga (UK) *Pharmacologic class:* Histamine₂ (H₂)-receptor antagonist *Therapeutic class:* Antiulcer drug *Pregnancy risk category B* Action Inhibits histamine action at H₂-receptor sites in gastric parietal cells, reducing gastric acid secretion and pepsin production Availability Capsules: 150 mg, 300 mg Oral solution: 15 mg/ml Tablets: 75 mg Indications and dosages ➣ Active duodenal ulcer Adults: 300 mg P.O. daily at bedtime or 150 mg b.i.d. for up to 8 weeks ➣ Maintenance of healed duodenal ulcers Adults and children ages 12 and older: 150 mg P.O. daily at bedtime for up to 1 year ➣ Esophagitis and associated heartburn caused by gastroesophageal reflux disease (GERD) Adults: 150 mg P.O. b.i.d. for up to 12 weeks ➣ Active benign gastric ulcer Adults: 150 mg P.O. b.i.d. or 300 mg P.O. once daily at bedtime ➣ Erosive esophagitis; GERD Children ages 12 and older: 150 mg P.O. b.i.d. for up to 8 weeks Dosage adjustment • Moderate to severe renal impairment • Elderly patients Contraindications • Hypersensitivity to drug or other H₂-receptor antagonists Precautions Use cautiously in: • mild renal impairment • elderly patients • pregnant or breastfeeding patients • children younger than age 12 (safety and efficacy not established). Administration • Give with or without food. • If patient is to take drug twice daily, give one dose in morning and one at bedtime. Adverse reactions CNS: dizziness, drowsiness, headache, anxiety, nervousness, insomnia, abnormal dreams, asthenia CV: chest pain EENT: amblyopia, sinusitis, rhinitis, pharyngitis GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, flatulence, anorexia, dry mouth Hematologic: anemia Musculoskeletal: back pain, myalgia Respiratory: cough Skin: rash, pruritus Other: tooth disorder, infection, fever, pain Interactions Drug-drug. Salicylates (high doses): increased salicylate blood level Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase: elevated levels Urobilinogen tests using Multistix: false-positive result Drug-herbs. Pennyroyal: altered rate of herbal metabolite formation Patient monitoring • Monitor liver and renal function tests. • Check temperature; watch for fever and other signs and symptoms of infection. Patient teaching • Advise patient to take once-daily dose at bedtime with or without food, or twice-daily doses in morning and at bedtime. • Instruct patient to take exactly as prescribed. Caution him not to take other OTC drugs (especially aspirin). • Tell patient to report signs and symptoms of infection. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above. nizatidine (nī-zăt′ĭ-dēn′)n. A histamine receptor antagonist, C₁₂H₂₁N₅O₂S₂, that inhibits the secretion of gastric acid and is used to treat duodenal and gastric ulcers and gastroesophageal reflux disease. nizatidine A H2-receptor antagonist used to treat peptic ulcer disease. Adverse reactions Diarrhoea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynaecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis. nizatidine Axid^® Therapeutics An H₂-receptor antagonist used to treat peptic ulcer disease Adverse reactions Diarrhea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis, etc. See Histamine receptor antagonists. nizatidine An H₂ RECEPTOR ANTAGONIST drug used to prevent and treat peptic ulcers. Brand names are Axid and Zinga.
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nizatidine

ni·zat·i·dine

nizatidine

nizatidine

nizatidine

Action

Availability

Indications and dosages

Dosage adjustment

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

nizatidine

nizatidine

nizatidine

nizatidine