Lomotil
Noun | 1. | Lomotil - trade name of an antidiarrheal |
单词 | lomotil | |||
释义 | Lomotil
LomotilLomotil[lo´mo-til]diphenoxylate hydrochloride and atropine sulfate (co-phenotrope (UK))Pharmacologic class: Anticholinergic, meperidine congener Therapeutic class: Antidiarrheal Controlled substance schedule V Pregnancy risk category C ActionActs on smooth muscle of GI tract by decreasing peristalsis, which inhibits motility. (Small amount of atropine is added to reduce abuse potential.) AvailabilityLiquid: 2.5 mg diphenoxylate and 0.025 mg atropine/5 ml Tablets: 2.5 mg diphenoxylate and 0.025 mg atropine Indications and dosages➣ Diarrhea Adults: Initially, 5 mg P.O. three to four times daily, then 5 mg/day as needed (not to exceed 20 mg/day). Decrease dosage when desired response occurs. Children: Initially, 0.3 to 0.4 mg/kg P.O. (liquid only) daily in four divided doses. Decrease dosage when desired response occurs. Dosage adjustment• Elderly patients Contraindications• Hypersensitivity to drug • Obstructive jaundice • Diarrhea associated with pseudomembranous colitis or enterotoxinproducing bacteria • Angle-closure glaucoma • Concurrent MAO inhibitor use • Children younger than age 2 PrecautionsUse cautiously in: • inflammatory bowel disease; prostatic hypertrophy; severe hepatic disease (use with extreme caution) • concurrent use of drugs that cause physical dependence; history of physical drug dependence • elderly patients • pregnant or breastfeeding patients • children (safety not established in children younger than age 12). AdministrationSee Don't confuse brand name Lomotil with Lamictal (an anticonvulsant). Serious errors have been reported. • Withhold drug if patient has severe fluid or electrolyte imbalance. • Administer with food if GI upset occurs. See Don't give within 14 days of MAO inhibitors. Adverse reactionsCNS: dizziness, confusion, drowsiness, headache, insomnia, nervousness CV: tachycardia EENT: blurred vision, dry eyes GI: nausea, vomiting, constipation, epigastric distress, ileus, dry mouth GU: urinary retention Skin: flushing InteractionsDrug-drug. CNS depressants (including antihistamines, sedative-hypnotics, opioids): increased CNS depression Anticholinergic-like drugs (including tricyclic antidepressants, disopyramide): increased anticholinergic effects MAO inhibitors: hypertensive crisis Drug-diagnostic tests. Amylase: increased level Drug-herbs. Angel's trumpet, jimsonweed, scopolia: increased anticholinergic effects Drug-behaviors. Alcohol use: increased CNS depression Patient monitoringSee Assess for and report abdominal distention and signs or symptoms of decreased peristalsis. • Watch for signs and symptoms of dehydration. • Assess frequency and consistency of bowel movements. Patient teaching• Instruct patient to report persistent diarrhea. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • Tell patient that prolonged use may lead to dependence. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above. Lomotil(lō′mə-tĭl′)LomotilA brand name for a mixture of DIPHENOXYLATE and ATROPINE.Lomotil
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