isoproterenol hydrochloride

Isuprel

Pharmacologic class: Sympathomimetic, beta₁-adrenergic and beta₂-adrenergic agonist

Therapeutic class: Vasopressor, bronchodilator, antiasthmatic

Pregnancy risk category C

Action

Acts on beta₂-adrenergic receptors, causing relaxation of bronchial smooth muscle; acts on beta₁-adrenergic receptors in heart, causing positive inotropic and chronotropic effects and increasing cardiac output. Also lowers peripheral vascular resistance in skeletal muscle and inhibits antigen-induced histamine release.

Availability

Injection: 20 mcg/ml, 200 mcg/ml

Indications and dosages

➣ Shock

Adults and children: 0.5 to 5 mcg/minute by continuous I.V. infusion

➣ Heart block; ventricular arrhythmias

Adults: Initially, 0.02 to 0.06 mg I.V., then 0.01 to 0.2 mg I.V. or 5 mcg/minute I.V. Or initially, 0.2 mg I.M., then 0.02 to 1 mg I.M., depending on response. Or initially, 0.2 mg subcutaneously, then 0.15 to 0.2 mg subcutaneously, depending on response.

➣ Bronchospasm during anesthesia

Adults: 0.01 to 0.02 mg I.V., repeated when necessary

Contraindications

• Angina pectoris

• Angle-closure glaucoma

• Tachyarrhythmias

• Tachycardia or heart block caused by digitalis intoxication

• Ventricular arrhythmias that warrant inotropic therapy

• Labor, delivery, breastfeeding

Precautions

Use cautiously in:

• renal impairment, unstable vasomotor disorders, hypertension, coronary insufficiency, chronic obstructive pulmonary disease, diabetes mellitus, hyperthyroidism

• history of cerebrovascular accident or seizures

• elderly patients.

Administration

• Give each 0.02-mg I.V. dose by direct injection over 1 minute, or by I.V. infusion, as ordered. Always use continuous infusion pump to deliver infusion.

Adverse reactions

CNS: tremors, anxiety, insomnia, headache, dizziness, asthenia, nervousness

CV: palpitations, tachycardia, angina, rapid blood pressure changes, arrhythmias, cardiac arrest, Stokes-Adams attacks

EENT: pharyngitis, visual blurring

GI: nausea, vomiting, heartburn

Metabolic: hyperglycemia

Respiratory: bronchitis, dyspnea, increased sputum, pulmonary edema, bronchospasm

Skin: diaphoresis

Other: parotid gland swelling (with prolonged use), pallor

Interactions

Drug-drug. Cyclopropane, epinephrine, halogenated general anesthetics: increased risk of arrhythmias

Propranolol, other beta-adrenergic blockers: antagonism of bronchodilating effects

Drug-diagnostic tests. Glucose: increased level

Patient monitoring

• During I.V. administration, monitor ECG and vital signs carefully.

• Assess patient's response to drug and adjust I.V. infusion rate accordingly.

• Closely monitor arterial blood gas values, urine output, and central venous pressure.

See Stay alert for rebound bronchospasm.

Patient teaching

• Assure patient that he'll be monitored closely.

isoproterenol hydrochloride

(ī′sō-prə-târ′ə-nŏl′ -nôl)n. A sympathomimetic drug that causes bronchodilation, used parenterally to treat asthma.

isoproterenol hydrochloride

(ī″sō-prō″tĕr′ĭ-nŏl″) A sympathomimetic amine used to relieve bronchoconstriction in asthma and also as a cardiac stimulant in heart block.

CAUTION!

Overdosage administered by inhalation can be fatal.

单词	isoproterenol hydrochloride
释义	DictionarySeeIsuprelEncyclopediaSeeisoproterenol isoproterenol hydrochloride isoproterenol hydrochloride Isuprel *Pharmacologic class:* Sympathomimetic, beta₁-adrenergic and beta₂-adrenergic agonist *Therapeutic class:* Vasopressor, bronchodilator, antiasthmatic *Pregnancy risk category C* Action Acts on beta₂-adrenergic receptors, causing relaxation of bronchial smooth muscle; acts on beta₁-adrenergic receptors in heart, causing positive inotropic and chronotropic effects and increasing cardiac output. Also lowers peripheral vascular resistance in skeletal muscle and inhibits antigen-induced histamine release. Availability Injection: 20 mcg/ml, 200 mcg/ml Indications and dosages ➣ Shock Adults and children: 0.5 to 5 mcg/minute by continuous I.V. infusion ➣ Heart block; ventricular arrhythmias Adults: Initially, 0.02 to 0.06 mg I.V., then 0.01 to 0.2 mg I.V. or 5 mcg/minute I.V. Or initially, 0.2 mg I.M., then 0.02 to 1 mg I.M., depending on response. Or initially, 0.2 mg subcutaneously, then 0.15 to 0.2 mg subcutaneously, depending on response. ➣ Bronchospasm during anesthesia Adults: 0.01 to 0.02 mg I.V., repeated when necessary Contraindications • Angina pectoris • Angle-closure glaucoma • Tachyarrhythmias • Tachycardia or heart block caused by digitalis intoxication • Ventricular arrhythmias that warrant inotropic therapy • Labor, delivery, breastfeeding Precautions Use cautiously in: • renal impairment, unstable vasomotor disorders, hypertension, coronary insufficiency, chronic obstructive pulmonary disease, diabetes mellitus, hyperthyroidism • history of cerebrovascular accident or seizures • elderly patients. Administration • Give each 0.02-mg I.V. dose by direct injection over 1 minute, or by I.V. infusion, as ordered. Always use continuous infusion pump to deliver infusion. Adverse reactions CNS: tremors, anxiety, insomnia, headache, dizziness, asthenia, nervousness CV: palpitations, tachycardia, angina, rapid blood pressure changes, arrhythmias, cardiac arrest, Stokes-Adams attacks EENT: pharyngitis, visual blurring GI: nausea, vomiting, heartburn Metabolic: hyperglycemia Respiratory: bronchitis, dyspnea, increased sputum, pulmonary edema, bronchospasm Skin: diaphoresis Other: parotid gland swelling (with prolonged use), pallor Interactions Drug-drug. Cyclopropane, epinephrine, halogenated general anesthetics: increased risk of arrhythmias Propranolol, other beta-adrenergic blockers: antagonism of bronchodilating effects Drug-diagnostic tests. Glucose: increased level Patient monitoring • During I.V. administration, monitor ECG and vital signs carefully. • Assess patient's response to drug and adjust I.V. infusion rate accordingly. • Closely monitor arterial blood gas values, urine output, and central venous pressure. See Stay alert for rebound bronchospasm. Patient teaching • Assure patient that he'll be monitored closely. isoproterenol hydrochloride (ī′sō-prə-târ′ə-nŏl′ -nôl)n. A sympathomimetic drug that causes bronchodilation, used parenterally to treat asthma. isoproterenol hydrochloride (ī″sō-prō″tĕr′ĭ-nŏl″) A sympathomimetic amine used to relieve bronchoconstriction in asthma and also as a cardiac stimulant in heart block. CAUTION! Overdosage administered by inhalation can be fatal.
随便看	future-proof future-proofed future proofing future-proofing future proofing electronic files future proof your career future public land mobile telecommunications systems future public land mobile telecommunication system future quality management system future quest nevada, inc. future radioactive ion beam future radio wideband multiple access system future ram chips future rate agreement future rate agreements future readiness and optimized scheduling tool future readiness officer future ready workspace future regional engagement future rent increases future resource services corporation future rockstars of america future role playing game future roles of brokers futures