angiotensin-converting enzyme inhibitor

Thesaurus

Noun

angiotensin-converting enzyme inhibitor - an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to treat congestive heart failureACE inhibitorantihypertensive, antihypertensive drug - a drug that reduces high blood pressureCapoten, captopril - a drug (trade name Capoten) that blocks the formation of angiotensin in the kidneys resulting in vasodilation; used in the treatment of hypertension and congestive heart failureenalapril, Vasotec - an ACE inhibitor (trade name Vasotec) that blocks the formation of angiotensin in the kidney and so results in vasodilation; administered after heart attackslisinopril, Prinival, Zestril - an ACE inhibiting drug (trade names Prinival or Zestril) administered as an antihypertensive and after heart attacksAltace, ramipril - an ACE inhibitor (trade name Altace) used to treat high blood pressure or in some patients who have had a heart attackMavik, trandolapril - an ACE inhibiting drug (trade name Mavik) used in some patients after a heart attack or to treat hypertension

Angiotensin-converting enzyme inhibitor

ACE inhibitor

Angiotensin-converting enzyme inhibitor. Any of a family of drugs used to manage hypertension and reduce congestive heart failure (CHF)-related mortality and morbidity.
Examples
Bepridil, captopril, enalapril, lisionopril, losartan, quinapril, ramipril.
ACE inhibitor Effects in Heart Disease
Cardioprotective effects
• Restores balance between myocardial O2 supply and demand;
• Reduces left ventricular preload and afterload;
• Reduces left ventricular mass;
• Reduces sympathetic stimulation.
Vasculoprotective effects
• Antiproliferative and antimigratory effects on smooth muscle and inflammatory cells;
• Antiplatelet effects;
• Improved arterial compliance and tone;
• Improved and/or restored endothelial function;
• Antihypertensive;
• Possible antiatherosclerotic effect.
Pros
ACEIs are cardioprotective and vasculoprotective; cardioprotective effects include improved haemodynamics and electric stability, reduce sympathetic nervous system (SNS) activity and reduce left ventricular mass; vasculoprotective benefits include improved endothelial function, vascular compliance and tone, and direct antiproliferative and antiplatelet effects. ACEIs also stimulate prostaglandin (PG) synthesis, reduce the size of MIs, and reduce reperfusion injury and complex ventricular arrhythmias.
ACEIs are the treatment of choice in CHF with systolic dysfunction; they are vasodilators which decrease preload and afterload. ACEI-induced reduction in angiotensin II inhibits the release of aldosterone, which in turn reduces sodium and water retention which, by extension, reduce preload; ACEIs improve haemodynamics of CHF by reducing right atrial pressure, pulmonary capillary wedge pressure, arterial BP, as well as pulmonary and systemic vascular resistance; ACEIs increase cardiac and stroke indices by the left ventricle and reduce the right ventricular end-diastolic volumes, thereby increasing cardiac output, while simultaneously reducing cardiac load and myocardial O2 consumption.

Adverse effects
• Idiopathic—e.g., rashes, dysgeusia, BMsuppression.
• Class-specific—e.g., hypotension, renal impairment, hyperkaleamia, cough, angioneurotic oedema (the latter 2 of which are mediated by small vasoactive substances—e.g., bradykinin, substance P, and PG-related factors).

Angiotensin-converting enzyme (ACE) inhibitor

A drug that relaxes blood vessel walls and lowers blood pressure.Mentioned in: Congestive Cardiomyopathy, Heart Failure

angiotensin-converting enzyme inhibitor

noun

Synonyms for angiotensin-converting enzyme inhibitor

noun an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries

Synonyms

ACE inhibitor

Related Words

antihypertensive
antihypertensive drug
Capoten
captopril
enalapril
Vasotec
lisinopril
Prinival
Zestril
Altace
ramipril
Mavik
trandolapril