KDM2A

A gene on chromosome 11q13.2 that encodes lysine-specific demethylase 2A of the F-box protein family, which constitute one of the four subunits of the ubiquitin protein ligase complex called SCF (SKP1-cullin-F)-box (which is involved in phosphorylation-dependent ubiquitination). KDM2A may recognise and bind phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs, which are encoded by clusters of satellite repeats at the centromere. It is needed to sustain centromeric integrity and genomic stability, especially during mitosis.

单词	kdm2a
释义	KDM2A KDM2A A gene on chromosome 11q13.2 that encodes lysine-specific demethylase 2A of the F-box protein family, which constitute one of the four subunits of the ubiquitin protein ligase complex called SCF (SKP1-cullin-F)-box (which is involved in phosphorylation-dependent ubiquitination). KDM2A may recognise and bind phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs, which are encoded by clusters of satellite repeats at the centromere. It is needed to sustain centromeric integrity and genomic stability, especially during mitosis.
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