irbesartan

[ir″bĕ-sahr´tan] an angiotensin II receptor antagonist used as an antihypertensive, administered orally.

irbesartan

Aprovel (UK), Avapro

Pharmacologic class: Angiotensin II receptor antagonist

Therapeutic class: Antihypertensive

Pregnancy risk category D

FDA Box Warning

• When used during second or third trimester of pregnancy, drug may cause fetal injury and even death. Discontinue as soon as pregnancy is detected.

Action

Blocks aldosterone-secreting and potent vasoconstrictive effects of angiotensin II at tissue receptor sites, which reduces vasoconstriction and lowers blood pressure

Availability

Tablets: 75 mg, 150 mg, 300 mg

Indications and dosages

➣ Hypertension

Adults: 150 mg/day P.O.; may increase to 300 mg/day

➣ Nephropathy in patients with type 2 diabetes and hypertension

Adults: 300 mg P.O. once daily

Dosage adjustment

• Volume-depleted or hemodialysis patients receiving diuretics

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• heart failure, volume or sodium depletion, renal disease, hepatic impairment

• black patients

• females of childbearing age

• pregnant or breastfeeding patients

• children ages 18 and younger (safety not established).

Administration

• Administer with or without food.

• Know that drug may be given with other antihypertensive drugs.

Adverse reactions

CNS: dizziness, fatigue, headache, syncope

CV: orthostatic hypotension, chest pain, peripheral edema

EENT: conjunctivitis, vision disturbance, ear pain, sinus disorders

GI: nausea, diarrhea, constipation, abdominal pain, dry mouth

GU: albuminuria, renal failure

Metabolic: gout, hyperkalemia

Musculoskeletal: joint pain, back pain, muscle weakness

Respiratory: upper respiratory tract infection, cough, bronchitis

Other: dental pain

Interactions

Drug-drug. Diuretics, other antihypertensives: increased risk of hypotension

Lithium: increased lithium blood level

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effects

Potassium-sparing diuretics, potassium supplements: increased risk of hyperkalemia

Drug-diagnostic tests. Albumin: increased level

Drug-food. Salt substitutes containing potassium: increased risk of hyperkalemia

Patient monitoring

• Monitor vital signs, especially blood pressure.

• Watch for signs and symptoms of orthostatic hypotension.

• Watch blood pressure closely when volume depletion may cause hypotension (as in diaphoresis, nausea, vomiting, diarrhea, and postoperative period).

• Assess fluid intake and output. Keep patient well hydrated, especially if he's receiving diuretics concurrently.

• Monitor blood urea nitrogen and creatinine levels.

Patient teaching

• Tell patient he may take with or without food.

• Instruct patient to change position slowly and to stay well hydrated, to minimize blood pressure decrease when rising.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell female patient that drug has been linked to fetal injury and deaths. Caution her not to get pregnant during therapy. Advise her to use barrier contraception.

• Instruct female patient to report pregnancy.

• Instruct patient to report fever, chills, dizziness, severe vomiting, diarrhea, and dehydration.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

irbesartan

(ĭr′bə-sär′tn)n. An angiotensin II receptor blocker drug, C₂₅H₂₈ N₆O, used to treat hypertension.

irbesartan

Avapro^® Cardiology An ACE inhibitor used to manage HTN Lab ↑ in BUN Adverse effects Diarrhea, dyspepsia, musculoskeletal fatigue, URIs Contraindications Impaired renal function. See Hypertension. Cf Losartan.

irbesartan

An ANGIOTENSIN II ANTAGONIST drug used to treat high blood pressure (HYPERTENSION). Brand names are Aprovel and CoAprovel.

单词	irbesartan
释义	irbesartan ir·be·sar·tan I5250700 (ĭr′bə-sär′tn)n. An angiotensin II receptor blocker drug, C₂₅H₂₈ N₆O, used to treat hypertension. [irbe-, origin unknown + -sartan, angiotensin II receptor blocker suff.; see losartan.] Translations irbesartan irbesartan [ir″bĕ-sahr´tan] an angiotensin II receptor antagonist used as an antihypertensive, administered orally. irbesartan Aprovel (UK), Avapro *Pharmacologic class:* Angiotensin II receptor antagonist *Therapeutic class:* Antihypertensive *Pregnancy risk category D* FDA Box Warning • When used during second or third trimester of pregnancy, drug may cause fetal injury and even death. Discontinue as soon as pregnancy is detected. Action Blocks aldosterone-secreting and potent vasoconstrictive effects of angiotensin II at tissue receptor sites, which reduces vasoconstriction and lowers blood pressure Availability Tablets: 75 mg, 150 mg, 300 mg Indications and dosages ➣ Hypertension Adults: 150 mg/day P.O.; may increase to 300 mg/day ➣ Nephropathy in patients with type 2 diabetes and hypertension Adults: 300 mg P.O. once daily Dosage adjustment • Volume-depleted or hemodialysis patients receiving diuretics Contraindications • Hypersensitivity to drug or its components Precautions Use cautiously in: • heart failure, volume or sodium depletion, renal disease, hepatic impairment • black patients • females of childbearing age • pregnant or breastfeeding patients • children ages 18 and younger (safety not established). Administration • Administer with or without food. • Know that drug may be given with other antihypertensive drugs. Adverse reactions CNS: dizziness, fatigue, headache, syncope CV: orthostatic hypotension, chest pain, peripheral edema EENT: conjunctivitis, vision disturbance, ear pain, sinus disorders GI: nausea, diarrhea, constipation, abdominal pain, dry mouth GU: albuminuria, renal failure Metabolic: gout, hyperkalemia Musculoskeletal: joint pain, back pain, muscle weakness Respiratory: upper respiratory tract infection, cough, bronchitis Other: dental pain Interactions Drug-drug. Diuretics, other antihypertensives: increased risk of hypotension Lithium: increased lithium blood level Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effects Potassium-sparing diuretics, potassium supplements: increased risk of hyperkalemia Drug-diagnostic tests. Albumin: increased level Drug-food. Salt substitutes containing potassium: increased risk of hyperkalemia Patient monitoring • Monitor vital signs, especially blood pressure. • Watch for signs and symptoms of orthostatic hypotension. • Watch blood pressure closely when volume depletion may cause hypotension (as in diaphoresis, nausea, vomiting, diarrhea, and postoperative period). • Assess fluid intake and output. Keep patient well hydrated, especially if he's receiving diuretics concurrently. • Monitor blood urea nitrogen and creatinine levels. Patient teaching • Tell patient he may take with or without food. • Instruct patient to change position slowly and to stay well hydrated, to minimize blood pressure decrease when rising. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • Tell female patient that drug has been linked to fetal injury and deaths. Caution her not to get pregnant during therapy. Advise her to use barrier contraception. • Instruct female patient to report pregnancy. • Instruct patient to report fever, chills, dizziness, severe vomiting, diarrhea, and dehydration. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above. irbesartan (ĭr′bə-sär′tn)n. An angiotensin II receptor blocker drug, C₂₅H₂₈ N₆O, used to treat hypertension. irbesartan Avapro^® Cardiology An ACE inhibitor used to manage HTN Lab ↑ in BUN Adverse effects Diarrhea, dyspepsia, musculoskeletal fatigue, URIs Contraindications Impaired renal function. See Hypertension. Cf Losartan. irbesartan An ANGIOTENSIN II ANTAGONIST drug used to treat high blood pressure (HYPERTENSION). Brand names are Aprovel and CoAprovel.
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irbesartan

ir·be·sar·tan

irbesartan

irbesartan

irbesartan

FDA Box Warning

Action

Availability

Indications and dosages

Dosage adjustment

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

irbesartan

irbesartan

irbesartan