intermediate lymphocytic lymphoma

mantle cell lymphoma

An uncommon low-to-intermediate-grade non-Hodgkin lymphoma (NHL), which is a malignancy of naive B cells. It comprises ± 6% of NHL cases in the US, slightly higher in Europe. It is hard to treat and harder to cure. It is more common in men ≥ age 55.

Clinical findings
Massive splenomegaly, generalised lymphadenopathy, 1/3 present with “B” symptoms—i.e., fever, weight loss, night sweats.
Sites
Nodes, spleen, bone marrow, Waldeyer's ring, GI (lymphomatous polyposis), gallbladder.
DiffDx
• Small lymphocytic lymphoma/CLL
• MALT lymphoma
• Follicular lymphoma
Prognosis MCLs are often aggressive and involve the spleen, liver, bone marrow; they are regarded as incurable. Median 2- to 5-year survival. Cases with mutations in the immunoglobulin gene have better prognosis—40% achieve complete remission with chemotherapy.

intermediate lymphocytic lymphoma

Mantle-zone lymphoma Hematology An indolent B-cell lymphoma of older adults, related to small cell follicular lymphoma, composed of cells similar to those of WD lymphocytic lymphoma. See Lymphoma.

单词	intermediate lymphocytic lymphoma
释义	DictionarySeelymphoma intermediate lymphocytic lymphoma mantle cell lymphoma An uncommon low-to-intermediate-grade non-Hodgkin lymphoma (NHL), which is a malignancy of naive B cells. It comprises ± 6% of NHL cases in the US, slightly higher in Europe. It is hard to treat and harder to cure. It is more common in men ≥ age 55. Clinical findings Massive splenomegaly, generalised lymphadenopathy, 1/3 present with “B” symptoms—i.e., fever, weight loss, night sweats. Sites Nodes, spleen, bone marrow, Waldeyer's ring, GI (lymphomatous polyposis), gallbladder. DiffDx • Small lymphocytic lymphoma/CLL • MALT lymphoma • Follicular lymphoma Prognosis MCLs are often aggressive and involve the spleen, liver, bone marrow; they are regarded as incurable. Median 2- to 5-year survival. Cases with mutations in the immunoglobulin gene have better prognosis—40% achieve complete remission with chemotherapy. intermediate lymphocytic lymphoma Mantle-zone lymphoma Hematology An indolent B-cell lymphoma of older adults, related to small cell follicular lymphoma, composed of cells similar to those of WD lymphocytic lymphoma. See Lymphoma.
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