apolipoprotein C-III

ap·o·lip·o·pro·tein C-III

an apolipoprotein found in VLDL, HDL, and chylomicrons. It inhibits several lipases, including lipoprotein lipase.

APOC3

A gene on chromosome 11q23.1-q23.2 that encodes apolipoprotein C-III, a very low-density lipoprotein (VLDL) protein that inhibits lipoprotein and hepatic lipases; it is thought to delay catabolism of triglyceride-rich particles.

apolipoprotein C-III

An 8.7 kD protein and major constituent of chylomicrons and VLDL; it is a cofactor for sphingomyelinase, an inhibitor of lipoprotein lipase, may activate lecithin; cholesterol acyltransferase and modulate uptake of TG-rich remnants by hepatic receptors; Pts with apoC-III deficiency have an ↑ risk of CAD