apolipoprotein B-100

ap·o·lip·o·pro·tein B-100

an apolipoprotein found in LDL, VLDL, and IDL. The ligand for the LDL receptor; absent in certain types of abetalipoproteinemia.

APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).
Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.

apolipoprotein B-100

A 550 kD protein synthesized in the liver that is the major component in lipoproteins of endogenous origin–LDL, VLDL, IDL, provides the recognition signal targeting LDL to the LDL–apoB, E receptor and is considered to be the l'enfant terrible of ASHD Ref range 40 to 125 mg/dl Abnormal values ↑ in familial combined hyperlipidemia, acquired hyperlipidemia, in acute angina and MI

单词	apolipoprotein b-100
释义	EncyclopediaSeeapob apolipoprotein B-100 ap·o·lip·o·pro·tein B-100 an apolipoprotein found in LDL, VLDL, and IDL. The ligand for the LDL receptor; absent in certain types of abetalipoproteinemia. APOB A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver). Molecular pathology APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB. apolipoprotein B-100 A 550 kD protein synthesized in the liver that is the major component in lipoproteins of endogenous origin–LDL, VLDL, IDL, provides the recognition signal targeting LDL to the LDL–apoB, E receptor and is considered to be the l'enfant terrible of ASHD Ref range 40 to 125 mg/dl Abnormal values ↑ in familial combined hyperlipidemia, acquired hyperlipidemia, in acute angina and MI
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