interleukin-13

[‚in·tər¦lük·ən ′thər‚tēn] (immunology) A cytokine produced by activated T lymphocytes that inhibits inflammatory cytokine production induced by bacterial endotoxin and stimulates gamma-interferon production by natural killer cells, enhancing the effect of interleukin-2. Abbreviated IL-13.

interleukin-13

in·ter·leu·kin-13

(in'tĕr-lū'kin), A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation; its activity overlaps that of IL-4.

IL13

A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.
Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.

in·ter·leu·kin-13

(in'tĕr-lū'kin) A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation.

interleukin-13

A CYTOKINE produced by T LYMPHOCYTES that inhibits mononuclear cell inflammation.

单词	interleukin-13
释义	DictionarySeeinterleukin interleukin-13 interleukin-13 [‚in·tər¦lük·ən ′thər‚tēn] (immunology) A cytokine produced by activated T lymphocytes that inhibits inflammatory cytokine production induced by bacterial endotoxin and stimulates gamma-interferon production by natural killer cells, enhancing the effect of interleukin-2. Abbreviated IL-13. interleukin-13 in·ter·leu·kin-13 (in'tĕr-lū'kin), A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation; its activity overlaps that of IL-4. IL13 A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines. Molecular pathology IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms. in·ter·leu·kin-13 (in'tĕr-lū'kin) A cytokine derived from helper T-cell lymphocytes that inhibits mononuclear cell inflammation. interleukin-13 A CYTOKINE produced by T LYMPHOCYTES that inhibits mononuclear cell inflammation.
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