| Acronym | Definition |
|---|
| HLCS➣Holocarboxylase Synthetase |
| HLCS➣Half-Life: Counter-Strike (retail Counter Strike) |
| HLCS➣Horned Lizard Conservation Society |
| HLCS➣Houghton Lake Community Schools (Michigan) |
| HLCS➣Hyde Leadership Charter School (est. 2006; Bronx, New York, NY) |
| HLCS➣Harpoon Launch Control System |