| 单词 | igf-i | |||
| 释义 | IGF-IIGF1A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.Molecular pathology IGF1 mutations are a cause of insulin-like growth factor I deficiency. IGF-IInsulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarismIGF-I
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