(pir'ō-lēn-kar-boks'i-lāt dē-hī'drō'gen-ās), An enzyme that catalyzes the reversible reaction of 1-pyrroline 5-carboxylate and NAD+ to form l-glutamate and NADH; this enzyme plays a role in proline and ornithine metabolism; 1-pyrroline 5-carboxylate is in equilibrium with glutamate γ-semialdehyde; a deficiency of this enzyme is associated with type II hyperprolinemia.