icatibant
icatibant
(eye-kat-i-bant) icatibant,Firazyr
(trade name)Classification
Therapeutic: hereditary angioedema agentsPharmacologic: bradykinin b2 receptor antagonists
Indications
Action
Therapeutic effects
Pharmacokinetics
Time/action profile (reduction of symptoms)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
Subcut | within 1 hr | 2.0–2.6 hr† | 6–8 hr |
Contraindications/Precautions
Adverse Reactions/Side Effects
Central nervous system
- dizziness
Gastrointestinal
- ↑ transaminases
Local
- injection site reactions (most frequent)
Miscellaneous
- fever
Interactions
Drug-Drug interaction
May ↓ antihypertensive response to ACE inhibitors.Route/Dosage
Availability
Nursing implications
Nursing assessment
- Assess for symptoms of hereditary angioedema (submucosal or subcutaneous swelling) before and following treatment.
- Lab Test Considerations: May cause ↑ serum transaminases.
Potential Nursing Diagnoses
Ineffective breathing pattern (Indications)Implementation
- Additional doses may be administered with at least 6 hrs between injection if response is inadequate or symptoms recur. Do not administer more that 3 doses in 24 hr.
- Subcutaneous: Inject into abdominal area using the 25 gauge needle provided. Pinch fold of skin about 2–4 inches from belly button and inject at a 45°–90° angle. Avoid areas with scars or that are bruised, swollen, or painful. Do not use a different needle. Solution is clear and colorless; do not administer solutions that are discolored or contain particulate matter.
Patient/Family Teaching
- Instruct patient in recognizing symptoms of hereditary angioedema and correct technique for self-administration and disposal of equipment.
- Caution patient to seek medical attention immediately after injection if laryngeal swelling occurs.
- May cause tiredness, drowsiness, and dizziness. Caution patient to avoid driving, and other activities requiring alertness until response to medication is known.
- Advise patient to notify health care professional if fever, dizziness, or rash occur.
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes
- Resolution of signs and symptoms of an acute attack of hereditary angioedema.