alpha-ketoglutarate dehydrogenase

α-ke·to·glu·tar·ate de·hy·dro·gen·ase

an enzyme that catalyzes the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidized by NAD+; a complex that is a part of the tricarboxylic acid cycle. Synonym(s): 2-oxoglutarate dehydrogenase, α-ketoglutarate dehydrogenase complex