heavy guns

Oncology Referring to the use of aggressive chemotherapy, as in, ‘We’re going to hit Mr. Smith’s metastatic melanoma with heavy guns’—i.e., with multiple agents and/or therapeutic modalities
Vox populi Formidable, serious

heavy guns

adjective Formidable, serious Oncology Referring to the use of aggressive chemotherapy in advanced malignancy, which is hit with HGs–eg, multiple agents and therapeutic modalities. See Induction.