basaloid carcinoma

cloacogenic carcinoma

1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca. 2. in oncology, anal cancer arising proximal to the pectinate line. Synonym(s): basaloid carcinoma, cuboidal carcinoma [cloaca + -genic]

basaloid carcinoma

Gastrointestinal
A subtype of squamous cell carcinoma arising at the anorectal transition zone, which comprises 20% of all anal carcinomas. It is linked to HPV infection and more common in homosexual males, implicating anal intercourse as a vector. It has been variously reported as having either a better or worse prognosis than standard anal cancer.

Lung
A form of large cell carcinoma (non-small cell type), in which at least 50% of the cellular component is a basal cell carcinoma; it is often high-grade with 15–50 mitoses/10 HPF, and has a dismal prognosis by some authors as a type of squamous cell carcinoma.
IHC
p63, CK 5/6 +ve.
DiffDx
Poorly differentiated squamous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma.

Pattern
Small cuboidal or fusiform cells; lobular or tentacular invasion, peripheral palisading.

Prognosis
Probably worse than stage-matched squamous cell carcinoma.
Oral
Aggressive, rapidly growing; nodes are involved in 2/3 at time of diagnosis; distant metastases frequent (37–50%); age/site/stage/treatment matched-case control studies have the same prognosis as high-grade conventional SCC.

单词	basaloid carcinoma
释义	basaloid carcinoma cloacogenic carcinoma 1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca. 2. in oncology, anal cancer arising proximal to the pectinate line. Synonym(s): basaloid carcinoma, cuboidal carcinoma [cloaca + -genic] basaloid carcinoma Gastrointestinal A subtype of squamous cell carcinoma arising at the anorectal transition zone, which comprises 20% of all anal carcinomas. It is linked to HPV infection and more common in homosexual males, implicating anal intercourse as a vector. It has been variously reported as having either a better or worse prognosis than standard anal cancer. Lung A form of large cell carcinoma (non-small cell type), in which at least 50% of the cellular component is a basal cell carcinoma; it is often high-grade with 15–50 mitoses/10 HPF, and has a dismal prognosis by some authors as a type of squamous cell carcinoma. IHC p63, CK 5/6 +ve. DiffDx Poorly differentiated squamous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma. Pattern Small cuboidal or fusiform cells; lobular or tentacular invasion, peripheral palisading. Prognosis Probably worse than stage-matched squamous cell carcinoma. Oral Aggressive, rapidly growing; nodes are involved in 2/3 at time of diagnosis; distant metastases frequent (37–50%); age/site/stage/treatment matched-case control studies have the same prognosis as high-grade conventional SCC.
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