| 释义 |
HES6 HES6 A gene on chromosome 2q37.3 that encodes a transcription repressor which, while not binding DNA, suppresses HES1-mediated N-box-dependent transcriptional repression and the binding of HES1 to E-box sequences. HES6 also suppresses HES1-mediated inhibition of the ASCL1/MASH1 and TCF3/E47 heterodimer, allowing ASCL1 and TCF3 to upregulate transcription. It promotes cell differentiation. |