inactivated

Creutzfeldt-Jakob disease

Spastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie. Creutzfeld-Jakob disease agent–disinfection Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine or phenol-based detergents NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light

单词	inactivated
释义	inactivated in·ac·ti·vate I0071600 (ĭn-ăk′tə-vāt′)tr.v. in·ac·ti·vat·ed, in·ac·ti·vat·ing, in·ac·ti·vates To render inactive. in·ac′ti·va′tion n. Translations EncyclopediaSeepoliovirus vaccine inactivated Creutzfeldt-Jakob disease Spastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie. Creutzfeld-Jakob disease agent–disinfection Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine or phenol-based detergents NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light ThesaurusSeeinactivate
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inactivated

in·ac·ti·vate

inactivated

Creutzfeldt-Jakob disease