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DictionarySeeprogeriaHutchinson-Gilford syndrome
Hutchinson-Gilford syndrome[′həch·ən·sən ′gil·fərd ′sin‚drōm] (medicine) progeria Hutchinson-Gilford syndrome
pro·ge·ri·a (prō-jē'rē-ă), [MIM*176670] A condition of precocious aging with onset at birth or early childhood; characterized by growth retardation, a senile appearance with dry wrinkled skin, total alopecia, and birdlike facies; early occurrence of atherosclerosis in blood vessels and premature death due to coronary artery disease; genetics unclear. Synonym(s): Hutchinson-Gilford disease, Hutchinson-Gilford syndrome, premature senility syndrome [pro- + G. gēras, old age] Hutchinson-Gilford syndrome An AD condition seen in infancy, characterized by poor growth, early onset ASHD, periarticular fibrosis, ↓ subcutaneous fat, dwarfism, small face, beaked nose, baldness, brownish discolored parchment-like skin, poor dentition, poor muscle development, early death. Cf Cockayne syndrome. Gilford, Hastings, English physician, 1861-1941. Hutchinson-Gilford disease - see under Hutchinson, Sir JonathanHutchinson-Gilford syndrome - Synonym(s): Hutchinson-Gilford disease
Hutchinson, Sir Jonathan, English surgeon and pathologist, 1828-1913. Hutchinson crescentic notch - the semilunar notch on the incisal edge of Hutchinson teeth, encountered in congenital syphilis.Hutchinson disease - age-related guttate choroiditis.Hutchinson facies - the peculiar facial expression produced by drooping eyelids and motionless eyes in external ophthalmoplegia.Hutchinson freckle - a brown or black mottled, irregularly outlined, slowly enlarging lesion. Synonym(s): lentigo malignaHutchinson mask - the sensation experienced in tabetic neurosyphilis as if the face were covered with a mask or with cobwebs.Hutchinson patch - interstitial or parenchymatous keratitis giving rise to neovascularization of the cornea. Synonym(s): salmon patchHutchinson pupil - dilation of the pupil on the side of the lesion as part of a third nerve palsy.Hutchinson teeth - the teeth of congenital syphilis in which the incisal edge is notched and narrower than the cervical area. Synonym(s): notched teeth; screwdriver teeth; syphilitic teethHutchinson triad - parenchymatous keratitis, labyrinthine disease, and Hutchinson teeth, significant of congenital syphilis.Hutchinson-Gilford disease - a condition in which normal development in the first year is followed by gross retardation of growth, with dry wrinkled skin, total alopecia, and birdlike facies. Synonym(s): Hutchinson-Gilford syndrome; progeriaHutchinson-Gilford syndrome - Synonym(s): Hutchinson-Gilford disease |