| 释义 |
immunoglobulin A deficiency
immunoglobulin A deficiency[‚im·yə·nō‚gläb·yə·lən ¦ā di′fish·ən·sē] (immunology) An immune system disorder in which lower than normal amounts of immunoglobulin A are produced, resulting in increased susceptibility to infections such as chronic sinusitis, chronic pulmonary infections, and digestive problems. immunoglobulin A deficiency
immunoglobulin A deficiency Selective immunoglobulin A deficiency An AD condition that is the most common–1:600 in US–primary immune system disease, characterized by ↓ IgA to < 50 mg/L–normal 760-3900 mg/L; US 76-390 mg/dl Clinical ↓ immune function, ↑ RTIs, ↑ GI infections, autoimmune disease–eg, SLE, RA, arthritis; fatal hemolysis with blood transfusions, due to production of natural anti-IgA antibodies; other features include intestinal lymphangiectasia, gluten-sensitive enteropathy, allergies, 7S IgM antibodies to food, especially to milk Treatment IV immune globulin may be effective in some PtsAcronymsSeeIGAD |